Encouraging estrogen to take the least harmful path Indole-3-Carbinol (I3C) is a naturally occurring phytonutrient found in cruciferous vegetables. I3C initiates a series of reactions in the body that culminates in the elimination of estrogen. Researchers have observed that metabolism of estrogen occurs via one of two pathways: The harmful metabolic pathway, 16 alpha-hydroxylation, or the beneficial metabolic pathway, 2-hydroxylation. I3C encourages estrogen to take the least harmful path, a process that transforms estrogen into an antiestrogen. Because testosterone converts to estrogen even in the male body, I3C may support individuals who take testosterone precursors.
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