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Resveratrol - 60 caps

Code: 5512

Remarkable longevity enhancer & heart protector
For the past few years, resveratrol, a compound found in red grapes, has attracted widespread medical attention as the long sought-after fountain of youth. This is because research has begun to indicate that this phytonutrient does indeed seem to have longevity-enhancing effects and that it also can play a critical role in heart health.

Resveratrol promotes longevity
A groundbreaking study in 2006, investigating resveratrol in mammals, found that dietary supplementation with resveratrol protected obese mice on a high-calorie diet, improving their health and extending their life span. The study, conducted by the National Institute on Aging and a group co-led by pioneering researcher Dr. David Sinclair, compared three groups of middle-aged mice on three diets: a standard diet and a high-calorie diet (60 percent of calories from fat) with and without resveratrol (22.4 mg/kg/day). As expected, the mice in the untreated high-calorie group showed signs of obesity, developing enlarged livers, muscle inflammation, early signs of diabetes and heart disease, and dying much sooner than those on the standard diet. However, the resveratrol-supplemented mice developed none of these complications despite being obese. The mice given the high-fat diet and resveratrol lived as long as the mice fed the standard diet and up to 31 percent longer than the untreated obese group. This study dramatically showed for the first time that resveratrol increases life span for obese mammals, which would otherwise be expected to develop chronic diseases, especially type 2 diabetes, and to die sooner. Of the 153 biochemical pathways significantly altered in the high-calorie group, resveratrol opposed the effects of high-caloric intake in 144 of them (94 percent). Although the resveratrol-treated mice lost no weight, the supplement effectively offset the detrimental effects of a high-calorie diet by shifting their overall physiology towards that of the control group and preventing many of the obesity-associated pathologies.

Increasing energy expenditure
Soon after this study, French researchers shed some light as to what was going on. They fed healthy young mice large amounts of resveratrol (400 mg/kg/day) for 15 weeks. The team discovered that it greatly enhanced the aerobic capacity of the mice, doubling their physical endurance during exercise, increasing oxygen consumption efficiency, and significantly increasing grip strength. The investigators also found that the size and number of mitochondria, the powerhouses of cells, were dramatically increased in muscle fibers, which explained the greater energy-output capacity and endurance of the mice. As a result of the increased energy expenditure, the resveratrol-treated mice in the high-calorie group were able to burn off most of their excess calories rather than storing them as fat, preventing weight gain.

Cardiovascular protection
A study confirms that resveratrol confers special protection to the heart. Researchers divided two groups of middle-aged mice (14 months) to receive resveratrol (4.9 mg/kg/day) or a calorie-restricted diet (reduction of daily energy intake by 40 percent) and followed them until old age (30 months). They found that while aging altered gene-expression profiles in the heart, calorie restriction and resveratrol mitigated these changes by 90 and 92 percent, respectively, thus preventing the decline in cardiovascular function associated with aging. The researchers stated that “resveratrol at doses that can be readily achieved through dietary supplementation in humans is as effective as calorie restriction in opposing the majority of age-related transcriptional alterations in the aging heart.”

They also measured an indicator of cardiac function called the myocardial performance index, which normally increases with declining function and age. Both calorie restriction and resveratrol almost completely protected against this increase, unlike the control group, in which the index increased as expected. They concluded, “resveratrol mimics the effects of calorie restriction to prevent cardiac aging at both the transcriptional and functional levels.”

Many studies have found that resveratrol acts through several mechanisms to protect against acute and chronic heart disease. In an experimental study of cardiac hypertrophy, resveratrol helped improve blood flow by increasing the production of nitric oxide, the universal vasodilator, by 90 percent, while reducing levels of the artery-constricting angiotensin 2.

Osteoarthritis & neurodegenerative diseases
Resveratrol may also hold promise in osteoarthritis following studies that it inhibits the expression of proinflammatory mediators such as COX-217 and that it has a cartilage-protecting effect. Resveratrol also offers neuroprotective benefits. It has been shown to help degrade the destructive amyloid-beta protein implicated in Alzheimer’s disease and protect dopaminergic neurons against a neurotoxic compound that causes brain lesions in Parkinson’s disease.

Dosage:
Take 1–3 capsules per day in divided doses.

Product Specifications:
Serving Size: 1 Capsule
Amount Per Serving
Giant Knotweed (Polygonum cuspidatum)	100mg	*
extract (root) (supplying 20 mg trans-resveratrol)
*Daily Value not established
Other Ingredients: Hydroxypropylmethylcellulose (vegetarian capsule) and microcrystalline cellulose. Contains no added sugar, starch, salt, wheat, gluten, coloring, dairy products, flavoring or preservatives.

Quantity:

Price: $19.95