Turmeric Inhibits Multiple Sclerosis

INTRODUCTION
Researchers have determined that curcumin, a compound in the spice turmeric, can stop multiple sclerosis from developing in animals. Curcumin is emerging as a promising, disease-fighting nutrient, as it also has shown promise in blocking the development of Alzheimer's disease and cancer.

Researchers at Vanderbilt University injected 50- and 100-microgram doses of curcumin, three times per week, to a group of mice. These mice were bred to develop an autoimmune condition used as a model for multiple sclerosis because it results in the same gradual erosion of the protective myelin sheath surrounding nerve fibers as seen in MS. Throughout the month-long study, the researchers then observed whether the animals developed neurological impairment.

By the time the study was half over, mice untreated with curcumin developed a severe form of the autoimmune condition, with complete paralysis of both hind limbs. On the other hand, mice treated with 50-micrograms of curcumin experienced only minor symptoms, including a temporarily stiff tail. Mice that received the higher 100-microgram dose were completely protected from the MS-like disorder. The mice received doses roughly equivalent to those found in a typical Indian diet.

The researchers hypothesized that curcumin might work by blocking the production of IL-12, a protein that helps signal immune cells to begin attacking the myelin sheath.

Other studies have supported curcumin's ability to protect the nerves. Studies in mice suggest curcumin can slow Alzheimer's. In addition, researchers found low incidences of neurological diseases such as Alzheimer's in elderly Indian populations who consume curcumin as a regular part of their diet.

Reference:

Annual Experimental Biology Conference, New Orleans, April 23, 2002.

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